FITTO Journals

Vitamin B complex in management of COVID-19 related Anosmia

nSARS-CoV-2 has caused a worldwide pandemic since 2019. Majority of patients suffering from COVID-19 have reported respiratory symptoms like fever, cough and shortness of breath as their main symptoms. Among the patients suffering from non-respiratory symptoms of COVID-19 infection, anosmia has been one of the most common complaints. The reason behind loss of smell in COVID-19 may be explained by the fact that the nasal mucosa is rich in ACE-2 receptors. Since nSARS-CoV-2 enters the body through these receptors, involvement of the nasal mucosa is the chief cause of anosmia. This problem can range from 10-14 days with spontaneous remission, while some patients have not yet recovered and the damage seems to be permanent.

A trial was conducted with 300 patients (all tested RT-PCR positive for COVID-19) who complained of anosmia. All of these patients were given multivitamin tablets twice daily for 15days. Each of these tablets contained:

    • Thiamine (Vitamin B1) 10mg
    • Riboflavin (Vitamin B2) 10mg
    • Niacin (Vitamin B3) 45mg
    • Pantothenic acid (Vitamin B5) 50mg
    • Pyridoxine (Vitamin B6) 3mg
    • Methylcobalamin (Vitamin B12) 15mcg


201 patients (67%) reported their anosmia cured within 10 days of onset of symptoms whereas the median time of patients not receiving multivitamin is 18days. The results clearly show beneficial effects of Vitamin B complex.

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